3 Publications

3.1 Papers

3.1.6 Chronological list

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3.1.6.83 Volkman, S.K., Hartl, D.L., Wirth, D.F., Nielsen, K.M., Choi, M., Le Roch, K.G., Abagyan, R., Winzeler, E.A. (2002). Excess Polymorphisms in Genes for Membrane Proteins in Plasmodium Falciparum. Science 298, 216-218.

The detection of single-nucleotide polymorphisms in pathogenic microorganisms has normally been carried out by trial and error. Here we show that DNA hybridization with high-density oligonucleotide arrays provides rapid and convenient detection of single-nucleotide polymorphisms in Plasmodium falciparum, despite its exceptionally high adenine-thymine (AT) content (82%). A disproportionate number of polymorphisms are found in genes encoding proteins associated with the cell membrane. These genes are targets for only 22% of the oligonucleotide probes but account for 69% of the polymorphisms. Genetic variation is also enriched in subtelomeric regions, which account for 22% of the chromosome but 76% of the polymorphisms.