3 Publications
 Next
3.1 Papers
Section Intro | Molecular modeling | Bioinformatics | docking | Methods and algorithms | Applications | Chronological list

3.1.6 Chronological list
Section Contents | ref 1 | ref 2 | ref 3 | ref 4 | ref 5 | ref 6 | ref 7 | ref 8 | ref 9 | ref 10 | ref 11 | ref 12 | ref 13 | ref 14 | ref 15 | ref 16 | ref 17 | ref 18 | ref 19 | ref 20 | ref 21 | ref 22 | ref 23 | ref 24 | ref 25 | ref 26 | ref 27 | ref 28 | ref 29 | ref 30 | ref 31 | ref 32 | ref 33 | ref 34 | ref 35 | ref 36 | ref 37 | ref 38 | ref 39 | ref 40 | ref 41 | ref 42 | ref 43 | ref 44 | ref 45 | ref 46 | ref 47 | ref 48 | ref 49 | ref 50 | ref 51 | ref 52 | ref 53 | ref 54 | ref 55 | ref 56 | ref 57 | ref 58 | ref 59 | ref 60 | ref 61 | ref 62 | ref 63 | ref 64 | ref 65 | ref 66 | ref 67 | ref 68 | ref 69 | ref 70 | ref 71 | ref 72 | ref 73 | ref 74 | ref 75 | ref 76 | ref 77 | ref 78 | ref 79 | ref 80 | ref 81 | ref 82 | ref 83 | in press

3.1.6.54 Cardozo, T.J., and Abagyan, R. (1998). Molecular Modeling of the Domain Shared Between CED-4 and its Mammalian Homologue Apaf-1: A Structural Relationship to the G-proteins. J. of Mol. Model., 4, 83-93

Apoptosis (programmed cell death, PCD) is a characteristic type of cell death in which a regulated cellular response pathway mediated by cysteine proteases of the caspase family and Bcl-2 family proteins results in ordered and non-inflammatory involution of the cell. The CED-4 protein and its recently identified mammalian homologue Apaf-1 are critical but functionally uncharacterized components of the cell death machinery. We present here a three-dimensional molecular model for the central domain of CED-4, its alternatively spliced transcript (CED-4l) and Apaf-1. A novel protein family is identified and structure prediction for the family identifies a G-protein-like fold with high reliability. The three-dimensional model provides a potential structural explanation for the alternatively spliced variant as well as the known point mutations in CED-4. Regions of the CED-4 and Apaf-1 sequences which may interact with caspases and the Bcl-2 family are proposed. This new information provides a structural molecular framework for the interaction of CED-4-like proteins with the caspases and the Bcl-2 family in the regulation of apoptosis which is analogous to G-protein mediated interactions in well-defined signal transduction pathways.