Program

P.30 -- Poster, IWTCP-3

Date: Wednesday, 29 July 2015

Time: 08h30 - 10h00

pH-dependence of UV-visible Spectra of human-Neuroglobin, a sign of structural and dynamical properties based on Two-Level Model

T T Thao1, C T Anh1, S Bernad3, V Derrien3, N M Hoa2 and N A Viet1

1 Institute of Physics, Vietnam Academy of Science and Technology, 10 Dao Tan, Thu Le, Ba Dinh, Ha Noi, Vietnam 2 Hue University of Medicine and Pharmacy, Hue, Viet Nam 3Laboratoire de Chimie Physique, Université Paris-sud, 91405 Orsay, France

Neuroglobin (Ngb), a novel member of the Globin Group, was recently discovered by Burmester et al. (2000). Its uncertain physiological function makes lots of interest. The existing of a six-coordination heme geometry with proximal and distal histidines directly creates an axis within the heme iron, while the sixth ligand coordination binds to small ligand reversibly. In this report, the dissociation form of five-coordination and six-coordinated states of human-Ngb under pH condition have been interpreted by Two-level model.

Presenter: Nguyễn Minh Hoa