Program

P.24 -- Poster, IWTCP-3

Date: Wednesday, 29 July 2015

Time: 08h30 - 10h00

Non-additive effects of crowding and confinement on folding stability of proteins

Bui Phuong Thuy (1,2) and Trinh Xuan Hoang (1)

(1) Institute of Physics, Vietnam Academy of Science and Technology, 10 Dao Tan, Ba Dinh, Hanoi, Vietnam; (2) Nam Dinh University of Technology Education, Phu Nghia, Loc Ha, Nam Dinh, Vietnam

Folding of proteins in vivo typically occurs in a crowded solution and in confined spaces. It is generally accepted that the effects of crowding and confinement are equivalent in terms of enhancement of folding stability of proteins. In this study, by molecular dynamics simulations with simplified models, we show that these two effects are not additive to each other at high concentrations of crowders. It is suggested that at sufficiently high concentrations, the crowders may screen the confinement effects on folding of proteins.

Presenter: Bui Phuong Thuy