Program

P.23 -- Poster, IWTCP-3

Date: Wednesday, 29 July 2015

Time: 08h30 - 10h00

Folding and escape of nascent proteins at ribosomal exit tunnel

Bui Phuong Thuy (1,2) and Trinh Xuan Hoang (1)

(1) Institute of Physics, Vietnam Academy of Science and Technology, 10 Dao Tan, Ba Dinh, Hanoi, Vietnam; (2) Nam Dinh University of Technology Education, Phu Nghia, Loc Ha, Nam Dinh, Vietnam

We investigate the interplay between folding and escape of nascent proteins at the ribosomal exit tunnel by using Langevin dynamics with coarse-grained models. It is shown that at low temperature, folding co-occurs closely with the escape process resulting in an enhancement of the foldability of protein. The co-occurrence between the two processes, however, deteriorates as temperature increases. The escape process can be characterized as an anomalous diffusion with two different regimes for temperatures below and above the folding transition temperature. It is also shown that attractive interactions between amino acids and attractive sites on the tunnel wall lead to a free energy barrier against the escape of protein from the tunnel. It is suggested this barrier slows down the escape process in order to improve folding efficiency of the released protein.

Presenter: Bui Phuong Thuy