WWW Resources for Cytochrome P450 (CYP)

CYP Family

• Human  P450 Metabolism Database
• http://www.gentest.com/human_p450_database/index.html

Sequence of CYP

• CYP Allelic Nomenclature committee
• www.imm.ki.se/CYPalleles/
• drnelson.utmem.edu/CytochromeP450.html
• General Source for links to other CYP Web pages
• www.icgeb.trieste.it/p450/

CYP charts

• www.dml.georgetown.edu/depts/pharmacology/clinlist.html

The Cytochrome P-450 Enzymesystem

• http://www.edhayes.com/startp450.html

Drug Interactions

• The P450 Drug Interactions Home Page
• P450 Drug Interactions Computer Program
• http://www.mhc.com/Cytochromes/index.html

Adverse Effects and Drug Interactions

• Medscape DrugInfo with First Databank and ASHP
• http://promini.medscape.com/drugdb/search.asp

Comprehensive CYP metabolism lists

• http://www.gentest.com/human_p450_database/srchh450.asp

THE CYTOCHROME P-450 ENZYMESYSTEM　

• http://www.edhayes.com/startp450.html

FDA Medwatch  

• http://www.fda.gov/medwatch/safety.htm

Abstracts from the most recent 30 days for "CYP　metabolism" from PubMed

• http://www.issx.org/p450pg.htm/

Gentest Corporation

• http://www.gentest.com/human_p450_database/srchh450.asp

Related Sites
An review with many tables

• http://www.anaesthetist.com/physiol/basics/metabol/cyp/cyp.htm

A general article on drug metabolism that includes CYPs

• http://www.uspharmacist.com/newlook/ce/bioavail/lesson.cfm

Drug interactions of antidepressants in the elderly

• http://www.postgradmed.com/issues/1999/11_99/cadieux.htm

A clinical article on CYP3As

• http://www.uspharmacist.com/NewLook/DisplayArticle.cfm?item_num=20

A review article on clinical aspects of P450s

• www.aafp.org/afp/980101ap/cupp.html

A general article on drug interactions and CYPs

• www.postgradmed.com/issues/1999/02_99/johnson.htm

Images of P450s; and P450 in relation to the brain and cocaine

• http://home.earthlink.net/~cpardee/cellandmembrane.html

Review of interactions between alcohol and drugs

• www.rcpe.ac.uk/public/netleary.html

Sserotonergic antidepressants from a pharmacists point of view

• www.pharmacyconnects.com/content/phpractice/1998/08-98/ce-08-98.html

Drug interactions of newer atypical antipsychotics

• www.mmhc.com/hhcc/articles/HHCC9810/lam.html

P450 Protein
P450 Protein family review article,Cytochromes P450: a success story,Daniele Werck-Reichhart1, Rene Feyereisen2

• http://genomebiology.com/2000/1/6/reviews/3003/

David Nelson's homepage:David Nelson keeps an update of P450 sequences characterized in all organisms and is also the'P450 nomenclature committee', the person to contact to obtain a name for a new P450 sequence. Nelson also provides a simple introductory lecture on mammalian P450 enzymes and on all their hysiological and other functions.

• http://drnelson.utmem.edu/CytochromeP450.html

Home Page of the Human Cytochrome P450 (CYP):Allele Nomenclature Committee An update of the knowledge on allelic variants of
the human genes; also provides instructions on the submission of new variants.

• http://www.imm.ki.se/CYPalleles/

Directory of P450-containing systems:Lists P450 and related genes. More information on P450 structure, ligands, domain structure,electron donors and useful links on human alleles,drug metabolism, commercially available forms;also contains references.

• http://www.icgeb.trieste.it/~p450srv/

The P450 site at the University of Arizona:A site with a list, annotation and a physical map of Drosophila and A. thaliana P450s.

• http://ag.arizona.edu/p450/

in vitro drug metabolism methods or general information about cytochrome P450. 

Journal Articles

Crespi, CL, and VP Miller. 1999, Pharmacol. Ther., 84:121-131.

• The Use of Heterolously Expressed Drug Metabolizing Enzymes -- State of the Art and Prospects for the Future.

SE Clarke. 1998, Xenobiotica 28(12):1167-1202.

• In Vitro Assessment of Human Cytochrome P450.

Shiraga, T, Kaneko, H, Iwasaki, K, Tozuka, Z, Suzuki, A, and T Hata. 1999, Xenobiotica 29(3): 217-229.

• Identification of Cytochrome P450 Enzymes Involved in the Metabolism of Zotepine, an Antipsychotic Drug, in Human Liver Microsomes.

These papers review the RAF and RSF approach to designing experiments and interpreting data using cDNA-expressed enzymes.

Roy, P, Yu, LJ, Crespi, CL, and DJ Waxman. 1999, Drug Metab. Dispos. 27(6):655-666. 

• Development of a Substrate-Activity Based Approach to Identify the Major Human Liver P450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P450 Profiles.
  

Nakajima, M, Nakamura, S, Tokudome, S, Shimada, N, Yamazaki, H, and Yokoi, T, (1999) Drug Metab. Dispos., 27, 1381-1391. 

• Azelastine N-demethylation by Cytochrome P-450 CYP3A4, CYP2D6, and CYP1A2 in Human Liver Microsomes: Evaluation of an Approach to Predict the Contribution of Multiple CYPs.

Crespi, CL and BW Penman, (1997) Adv. Pharmacol. 43, 171-188.

• Use of cDNA-Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions,  

Books

Cytochrome P450 Protocols.
Phillips, IR and EA Shepard, eds. 1998. Methods in Molecular Biology Vol. 107, Humana Press. 

Introduction to Drug Metabolism.
Gibson, GG and P Skett. 1994, Blackie Academic & Professional.

Cytochromes P450 -- Metabolic and Toxicological Aspects
C Ioannides, ed. 1996, CRC Press.

Cytochrome P450 -- Structure, Mechanism, and Biochemistry.
PR Ortiz de Montellano, ed. 1995, Plenum Press.

P-glycoproteins (PGP)

• http://www.mhc.com/Cytochromes/Links.HTML

Discussion and interactions table

• http://www.mhc.com/PGP/

PGPs in AIDS - discussion and interactions table

• http://www.aidsinfonyc.org/tag/science/pgp.html

Drug Absorption / Metabolism
Abstracts from the most recent 30 days for "drug absorption" from PubMed

• http://www.issx.org/abspg.htm

Abstracts from the most recent 30 days for "Conjugation" from PubMed

• http://www.issx.org/conjpg.htm

• http://moldb.nihs.go.jp/phii/p450.html