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| Docking of a known RAR-alpha specific agonist. The RAR-alpha selective agonist Am580 was docked into the modeled ligand binding pocket of RAR-alpha. A: The complexed ligand (white sticks) superimposes withe the crystal structure of bound all-trans RA (green). Hydrogens are not shown for clarity. B: Am580 (CPK display) fits tightly into the receptor's pocket (yellow wire), but for a ketone oxygen, which shares an hydrogen with Ser234 of the receptor (displayed as stick).The receptor in vicinity of the ligand is shown as white ribbon. Carbons, hydrogens, oxygens and nitrogens are colored white, gray, red and blue respectively. (Image generated with MolSoft ICM) |
The development of new tools, techniques, algorithms and its use to decipher biological mysteries - these are our main goals.
Here we present our major research topics as well as the grants that support our work.
Our group is interested in four major research topics. More detailed descriptions are available for every project, as well as its corresponding papers.
Have a look at our gallery section too. Some results and concepts are nicely portrayed as graphical schemes and representations.