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Genomes to Life Roadmap April 2001 Cover Letter Executive Summary Introduction Beyond the Sequences Challenges of Complexity Economies of Nature The Microbial Cell Project: A First Step Program Management Biological Solutions for DOE Missions Ethical, Legal, and Social Issues Technology Needs DNA, RNA, Protein, Protein Machine, and Functional Analyses and Imaging Sampling and Sample Production Informatics, Modeling, and Simulation DOE Strengths and Capabilities Genomes to Life: A Primer Technical Goals Goal 1: Identify and Characterize the Molecular Machines of Life -- the Multiprotein Complexes That Execute Cellular Functions and Govern Cell Form The Machines of Life Goal 2: Characterize Gene Regulatory Networks Gene Regulatory Networks Goal 3: Characterize the Functional Repertoire of Complex Microbial Communities in Their Natural Environments at the Molecular Level Exploring the Functions of Microbes and Their Communities Goal 4: Develop the Computational Methods and Capabilities to Advance Understanding of Complex Biological Systems and Predict Their Behavior Computational Biology Research and Development Goals (table) Models for the New Biology Special Section: Some Federal Programs Complementary to Genomes to Life Appendicies Technology Fundamentals DOE Partners in Genomes to Life Program Web Sites of Research Programs and Resources Complementary to Genomes to Life

Printable version of Genomes to Life: a list of pdf files Order the printed version (mailed in 2-3 weeks) DOE/SC-0036 Document prepared by the Human Genome Management Information System Oak Ridge National Laboratory Oak Ridge, Tennessee

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Program of the
Office of Biological and Environmental Research (sponsors of the Human Genome Program)
and
Office of Advanced Scientific Computing Research
of the
U.S. Department of Energy Office of Science