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MDL® Discovery Experiment Management
MDL® Discovery Predictive Science
MDL® Toxicity Database
MDL Toxicity Database is a structure-searchable bioactivity database of over 150,000 toxic chemical substances. An Oracle-based system accessible through MDL ISIS/Host, Toxicity Database contains data from in vivo and in vitro studies of acute toxicity, mutagenicity, skin and eye irritation, tumorigenicity and carcinogenicity, reproductive effects and multiple dose effects. Information covered includes species of organism studied, tissue studied, route of administration, dose, endpoint, toxic effects descriptors, severity of response, CAS Registry Numbers, Beilstein Registry Numbers, chemical names and synonyms, molecular formula and molecular weight. The Toxicity database includes references to the original publications reporting the toxicity data and to relevant review articles when applicable.Toxicity Database is compatible with MDL LitLink Server - Pro Server 1.0 and higher and MDL LitLink Server - Standard Server 1.1 and higher, enabling scientists to hyperlink directly to those electronic journal articles to which you have access rights. LitLink Server locates documents cited in your Windows or Web applications. You must have appropriate access rights to these third-party documents. MDL is not necessarily affiliated with, endorsed, or sponsored by the publishers of these journals.
Coverage:
1902 - present.
Data is abstracted from over 2,950 worldwide sources, including: scientific journals, conference proceedings, symposia reports, reviews, and more. MDL obtains the data found in Toxicity from the Registry of Toxic Effects of Chemical Substances (RTECS) database. Toxicity Database is updated quarterly.Focus:
Toxic properties of chemical substances.
Drugs and drug development compounds constitute 65% of the substances covered. The remainder consists of agrochemicals, industrial and petrochemicals, plastics, flavors and fragrances, plant and animal extracts, inorganic compounds, organometallics, and others.Toxicity Database can also be used in conjunction with the MDL Metabolite Database; the MDL ISIS Toxicity Finder, and the MDL Metabolite Browser; links are based upon chemical structure. While the scientist is browsing either database, and a structure displays that is registered to both Toxicity Database and Metabolite Database, a single click enables transfer between the databases to view relevant toxicity and biotransformation data.
Source:
Registry of Toxic Effects of Chemical Substances (RTECS) database produced by the National Institute of Occupational Safety and Health (NIOSH).
Size: 151,310 compounds
Disk space:
1,200,000 VMS blocks (Open VMS)
693 MB (AIX/IRIX and Windows NT)CAS is a registered trademark of Chemical Abstracts Service.
Last Updated 24-Apr-2002
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