volume 32 no. 2 pp 213 - 332     Editorial   Genomics for all  pp 213 - 214 doi:10.1038/ng1002-213       News & Views   Blinded by the light  pp 215 - 216 Samuel G. Jacobson & Roderick R. McInnes    SEE ALSO 254 doi:10.1038/ng1002-215     Quorum sensing in Vibrio cholerae  pp 217 - 218 Miguel Cámara, Andrea Hardman, Paul Williams & Debra Milton doi:10.1038/ng1002-217     The pit, the cleft and the web  pp 219 - 220 Maximilian Muenke    SEE ALSO 285 doi:10.1038/ng1002-219     The tail does not always wag the dog  pp 221 - 222 Karolin Luger    SEE ALSO 273 Published online: 16 September 2002, doi:10.1038/ng1000     Securin a new role for itself  pp 222 - 224 Anil K. Rustgi    SEE ALSO 306 doi:10.1038/ng1002-222     TOUCHINGbase  p 225 doi:10.1038/ng1002-225

Book Review   Genetic Destinies   pp 227 - 228 by Peter Little Reviewed by C J Epstein doi:10.1038/ng1002-227       Commentary   Top ten biotechnologies for improving health in developing countries  pp 229 - 232 A S Daar, H Thorsteinsdóttir, D K Martin, A C Smith, S Nast & P A Singer doi:10.1038/ng1002-229

Correspondence   Risk for familial breast cancer increases with age  p 233 K Hemminki & C Granström doi:10.1038/ng1002-233     Reply to "Risk for familial breast cancer increases with age"  p 234 J Peto doi:10.1038/ng1002-234       Brief Communications   Facioscapulohumeral muscular dystrophy is uniquely associated with one of the two variants of the 4q subtelomere  pp 235 - 236 R J L F Lemmers, P de Kievit, L Sandkuijl, G W Padberg, G -J B van Ommen, R R Frants & S M van der Maarel Published online: 23 September 2002, doi:10.1038/ng999

Articles   Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease  pp 237 - 244 M M Carrasquillo, A S McCallion, E G Puffenberger, C S Kashuk, N Nouri & A Chakravarti Published online: 23 September 2002, doi:10.1038/ng998     Regulation of insulin action and pancreatic -cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1  pp 245 - 253 J Nakae, W H Biggs III, T Kitamura, W K Cavenee, C V E Wright, K C Arden & D Accili Published online: 3 September 2002, doi:10.1038/ng890     Evidence for two apoptotic pathways in light-induced retinal degeneration  pp 254 - 260 W Hao, A Wenzel, M S Obin, C -K Chen, E Brill, N V Krasnoperova, P Eversole-Cire, Y Kleyner, A Taylor, M I Simon, C Grimm, C E Remé & J Lem    SEE ALSO 215 Published online: 3 September 2002, doi:10.1038/ng984

Letters   Variation in gene expression within and among natural populations  pp 261 - 266 M F Oleksiak, G A Churchill & D L Crawford Published online: 3 September 2002, doi:10.1038/ng983     Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy  pp 267 - 272 H Takashima, C F Boerkoel, J John, G M Saifi, M A M Salih, D Armstrong, Y Mao, F A Quiocho, B B Roa, M Nakagawa, D W Stockton & J R Lupski Published online: 16 September 2002, doi:10.1038/ng987     A core nucleosome surface crucial for transcriptional silencing  pp 273 - 279 J -H Park, M S Cosgrove, E Youngman, C Wolberger & J D Boeke    SEE ALSO 221 Published online: 16 September 2002, doi:10.1038/ng982     Chromosomal instability in ulcerative colitis is related to telomere shortening  pp 280 - 284 J N O'Sullivan, M P Bronner, T A Brentnall, J C Finley, W -T Shen, S Emerson, M J Emond, K A Gollahon, A H Moskovitz, D A Crispin, J D Potter & P S Rabinovitch Published online: 23 September 2002, doi:10.1038/ng989     Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes  pp 285 - 289 S Kondo, B C Schutte, R J Richardson, B C Bjork, A S Knight, Y Watanabe, E Howard, R L L Ferreira de Lima, S Daack-Hirsch, A Sander, D M McDonald-McGinn, E H Zackai, E J Lammer, A S Aylsworth, H H Ardinger, A C Lidral, B R Pober, L Moreno, M Arcos-Burgos, C Valencia, C Houdayer, M Bahuau, D Moretti-Ferreira, A Richieri-Costa, M J Dixon & J C Murray    SEE ALSO 219 Published online: 3 September 2002, doi:10.1038/ng985     Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse  pp 290 - 295 D Kapfhamer, O Valladares, Y Sun, P M Nolan, J J Rux, S E Arnold, S C Veasey & M Buan Published online: 16 September 2002, doi:10.1038/ng991     An initiation site for meiotic crossing-over and gene conversion in the mouse  pp 296 - 299 H Guillon & B de Massy Published online: 16 September 2002, doi:10.1038/ng990     The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin  pp 300 - 305 G Mollet, R Salomon, O Gribouval, F Silbermann, D Bacq, G Landthaler, D Milford, A Nayir, G Rizzoni, C Antignac & S Saunier Published online: 9 September 2002, doi:10.1038/ng996     Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis  pp 306 - 311 J A Bernal, R Luna, Á Espina, I Lázaro, F Ramos-Morales, F Romero, C Arias, A Silva, M Tortolero & J A Pintor-Toro    SEE ALSO 222 Published online: 23 September 2002, doi:10.1038/ng997     Bi-allelic inactivation of TCF1 in hepatic adenomas  pp 312 - 315 O Bluteau, E Jeannot, P Bioulac-Sage, J M Marqués, J -F Blanc, H Bui, J -C Beaudoin, D Franco, C Balabaud, P Laurent-Puig & J Zucman-Rossi Published online: 23 September 2002, doi:10.1038/ng1001     ASPM is a major determinant of cerebral cortical size  pp 316 - 320 J Bond, E Roberts, G H Mochida, D J Hampshire, S Scott, J M Askham, K Springell, M Mahadevan, Y J Crow, A F Markham, C A Walsh & C G Woods Published online: 23 September 2002, doi:10.1038/ng995     Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk  pp 321 - 325 J Xu, S L Zheng, A Komiya, J C Mychaleckyj, S D Isaacs, J J Hu, D Sterling, E M Lange, G A Hawkins, A Turner, C M Ewing, D A Faith, J R Johnson, H Suzuki, P Bujnovszky, K E Wiley, A M DeMarzo, G S Bova, B Chang, M C Hall, D L McCullough, A W Partin, V S Kassabian, J D Carpten, J E Bailey-Wilson, J M Trent, J Ohar, E R Bleecker, P C Walsh, W B Isaacs & D A Meyers Published online: 16 September 2002, doi:10.1038/ng994     Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy  pp 326 - 330 J Robitaille, M L E MacDonald, A Kaykas, L C Sheldahl, J Zeisler, M -P Dubé, L -H Zhang, R R Singaraja, D L Guernsey, B Zheng, L F Siebert, A Hoskin-Mott, M T Trese, S N Pimstone, B S Shastry, R T Moon, M R Hayden, Y P Goldberg & M E Samuels Published online: 12 August 2002, doi:10.1038/ng957

Errata   Erratum: Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae  p 331 T H M Ottenhoff, F A W Verreck, E G R Lichtenauer-Kaligis, M A Hoeve, O Sanal & J T van Dissel doi:10.1038/ng1002-331a     Erratum: Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret  p 331 E Batourina, C Choi, N Paragas, N Bello, T Hensle, F D Constantini, A Schuchardt, R L Bacallao & C L Mendelsohn doi:10.1038/ng1002-331b     Erratum: Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice  p 331 C C Hoogenraad, B Koekkoek, A Akhmanova, H Krugers, B Dortland, M Miedema, A van Alphen, W M Kistler, M Jaegle, M Koutsourakis, N Van Camp, M Verhoye, A van der Linden, I Kaverina, F Grosveld, C I De Zeeuw & N Galjart doi:10.1038/ng1002-331c     Erratum: High-throughput retroviral tagging to identify components of specific signaling pathways in cancer  p 331 H Mikkers, J Allen, P Knipscheer, L Romeyn, A Hart, E Vink & A Berns doi:10.1038/ng1002-331d     Erratum: New genes involved in cancer identified by retroviral tagging  p 331 T Suzuki, H Shen, K Akagi, H C Morse III, J D Malley, D Q Naiman, N A Jenkins & N G Copeland doi:10.1038/ng1002-331e     Erratum: A User's Guide to the Human Genome  p 332 T G Wolfsberg, K A Wetterstrand, M S Guyer, F S Collins & A D Baxevanis doi:10.1038/ng1002-332