Programme

I.8 -- Invited, VCTP-44

Date: Tuesday, 30 July 2019

Time: 14:30 - 15:00

Ultrasound interacts with biological systems

Nguyen Hoang Phuong (1,2)

(1) CNRS, Université de Paris, UPR 9080, Laboratoire de Biochimie Théorique, 13 rue Pierre et Marie Curie, F-75005, Paris, France; (2) Institut de Biologie Physico-Chimique, Fondation Edmond de Rotschild, PSL Research University, Paris, France

Ultrasound has a wide range of medical applications. Nowadays, the diagnostic and therapeutic ultrasound procedures are routinely used, but effects of ultrasound on biological systems at the molecular level are, however, not fully understood even for the simplest biological components such as cell membranes and proteins. This limits the development and application of ultrasound in the emerging important fields such drug delivery to the brain or cancer cells. In principle, the molecular dynamics simulation method can provide molecular insights into the interaction between ultrasound and biological systems. However, its applications in this field are still at infancy. In this talk, we will present our recent development of the methods for performing molecular dynamics simulations under focused ultrasound and ultrasound induced bubble cavitation. The applications of the methods are illustrated with the studies of the bubble cavitation induced amyloid fibril dissociation, lipid cell membrane pore formation, damage and molecular nanometers propelled by bubble.

Presenter: Nguyen Hoang Phuong