Program

O.8 -- Oral, NCTP-42

Date: Monday, 31 July 2017

Time: 15h00 - 15h20

Behavior of heart rate responds to switching frequency

Le Duy Manh (1), Pik-Yin Lai (2), C. K. Chan (2,3)

(1) Institute of Physics, Vietnam Academy of Science and Technology, Hanoi, Vietnam; (2) Department of Physics and Graduate Institute of Physics, National Central University, Taoyuan, Taiwan; (3) Institute of Physics, Academia Sinica, Taipei, Taiwan

Recent pacing experiments with hearts of rat have discovered that the contractile response of the hearts can have an unexpected slow non-monotonic response. This later observation have not been reported and cannot be explained by the existing excitation-contraction (EC) coupling model. An improvement of discrete map model of the EC coupling is developed to understand these experimental findings. It is found that the biphasic response and the slow time scale can be reproduced when the model is integrated with the role of a very important enzyme, namely CaMKII – a protein complex that is well known to play an important role in Calcium homeostasis of the cardiac cells. Our improved model gives quite good agreement with the experimental data of heart rate in responding to switching frequency.

Presenter: Le Duy Manh